India developed several industrial clusters nationwide, including in the state of Tamil Nadu to boost manufacturing. Three coastal cities, namely, Thoothukudi, Cuddalore, and Manali are developed as industrial clusters in Tamil Nadu. For the first time, we documented air quality trends in these industrial cluster cities of Tamil Nadu and compared them with those in Indian major cities, namely, Delhi, Mumbai, Kolkata, and Chennai. Between 2015-2020, data on key air quality parameters, such as particulate matter (PM10 and PM2.5), nitrogen dioxide (NO2), sulphur dioxide (SO2), and National Air Quality Index (NAQI) measured in these cities were analyzed.