The COVID-19 pandemic spread all over the world in early 2020. India imposed a nationwide lockdown on March 25, 2020, for more than a month to contain the COVID-19 infection. During the nationwide lockdown, transport, industries, and commercial activities were suspended, except for essential services. We made a detailed analysis of the impacts of COVID-19 on air quality in India by using the data from more than 200 Continuous Ambient Air Quality Monitoring Stations (CAAQMS) and reported a change in the National Air Quality Index (NAQI), spatial distribution and concentration levels of PM10, PM2.5, CO, NO2, SO2, and O3 from January to April 2020 nationwide and in five major cities, namely, Delhi, Mumbai, Kolkata, Chennai, and Hyderabad.